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Scientific articles

Neutrophils Transport Antigen from the Dermis to the Bone Marrow, Initiating a Source of Memory CD8+ T Cells

Authors: Darragh Duffy, Hélène Perrin, Valérie Abadie, Nora Benhabiles, Alexandre Boissonnas, Christelle Liard, Benjamin Descours, Damien Reboulleau, Olivia Bonduelle, Bernard Verrier, Nico Van Rooijen, Christophe Combadière, Béhazine Combadière

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Recombinant retrovirus-derived virus-like particle-based vaccines induce hepatitis C virus-specific cellular and neutralizing immune responses in mice

Authors: Christophe Hureta, Delphine Desjardinsa, Mathilde Miyaloua, Béatrice Levachera, Martin Amadoudji Zina, Olivia Bonduelle, Béhazine Combadière, Charlotte Dalbaf, David Klatzmanna, Bertrand Bellier

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Protective effect of CX3CR1+ dendritic cells in a vaccinia virus pulmonary infection model

Authors: Bonduelle O, Duffy D, Verrier B, Combadière C, Combadière B.

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Microneedle mediated intradermal delivery of adjuvanted recombinant HIV-1 CN54gp140 effectively primes mucosal boost inoculations

Authors: Aditya Pattania, Paul F. McKayb, Martin J. Garlanda, Rhonda M. Currana, Katarzyna Migalskaa, Corona M. Cassidya, R. Karl Malcolma, Robin J. Shattockb, Helen O. McCarthya, Ryan F. Donnelly

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Saquinavir inhibits early events associated with establishment of HIV-1 infection: potential role for protease inhibitors in prevention

Authors: Stefanidou M, Herrera C, Armanasco N, Shattock RJ

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Preclinical evaluation of the HIV-1 fusion inhibitor L’644 as a potential candidate microbicide

Authors: Harman S, Herrera C, Armanasco N, Nuttall J, Shattock RJ

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Molecular investigations into vaginal immunization with HIV gp41 antigenic construct H4A in a quick release solid dosage form

Authors: Pattani A, McKay PF, Curran RM, McCaffrey J, Gupta PN, Lowry D, Kett VL, Shattock RJ, McCarthy HO, Malcolm RK

Read full article on Molecular investigations into vaginal immunization with HIV gp41 antigenic construct H4A in a quick release solid dosage form>

Uncommon pathways of immune escape attenuate HIV-1 integrase replication capacity

Authors: Brockman MA, Chopera DR, Olvera A, Brumme CJ, Sela J, Markle TJ, Martin E, Carlson JM, Le AQ, McGovern R, Cheung PK, Kelleher AD, Jessen H, Markowitz M, Rosenberg E, Frahm N, Sanchez J, Mallal S, John M, Harrigan PR, Heckerman D, Brander C, Walker BD, Brumme ZL

Read full article on Uncommon pathways of immune escape attenuate HIV-1 integrase replication capacity>

CTL Responses of High Functional Avidity and Broad Variant Cross-Reactivity Are Associated with HIV Control

Authors: Beatriz Mothe, Anuska Llano, Javier Ibarrondo, Jennifer Zamarreño, Mattia Schiaulini, Cristina Miranda, Marta Ruiz-Riol, Christoph T. Berger, M. José Herrero, Eduard Palou, Montse Plana, Morgane Rolland, Ashok Khatri, David Heckerman, Florencia Pereyra, Bruce D. Walker, David Weiner, Roger Paredes, Bonaventura Clotet, Barbara K. Felber, George N. Pavlakis, James I. Mullins, Christian Brander

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Transcutaneous and intradermal vaccination

Authors: Behazine Combadiere and Christelle Liard

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Skin Penetration and Cellular Uptake of Amorphous Silica Nanoparticles with Variable Size, Surface Functionalization, and Colloidal Stability

Authors: Fiorenza Rancan, Qi Gao, Christina Graf, Stefan Troppens, Sabrina Hadam, Steffen Hackbarth, Cynthia Kembuan, Ulrike Blume-Peytavi, Eckart Rühl, Jürgen Lademann, and Annika Vogt

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Surface functionalization of silica nanoparticles supports colloidal stability in physiological media and facilitates internalization in cells

Authors: Christina Graf, Qi Gao, Irene Schütz, Christelle Njiki Noufele, Wentao Ruan, Uta Posselt, Elena Korotianskiy, Daniel Nordmeyer, Fiorenza Rancan, Sabrina Hadam, Annika Vogt, Jürgen Lademann, Volker Haucke, and Eckart Rühl

Read full article on Surface functionalization of silica nanoparticles supports colloidal stability in physiological media and facilitates internalization in cells>

Thymic stromal lymphopoietin (TSLP) acts as a potent mucosal adjuvant for HIV-1 gp140 vaccination in mice

Authors: Van Roey GA, Arias MA, Tregoning JS, Rowe G, Shattock RJ

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HLA class I protective alleles in an HIV-1-infected subject homozygous for CCR5-Δ32/Δ32

Authors: Ballana E, Riveira-Munoz E, Pou C, Bach V, Parera M, Noguera M, Santos JR, Badia R, Casadellà M, Clotet B, Paredes R, Martínez MA, Brander C, Esté JA

Read full article on HLA class I protective alleles in an HIV-1-infected subject homozygous for CCR5-Δ32/Δ32>

Low-replicating viruses and strong anti-viral immune response associated with prolonged disease control in a superinfected HIV-1 LTNP elite controller

Authors: María Pernas, Concepción Casado, Carolina Arcones, Anuska Llano, Víctor Sánchez-Merino, Beatriz Mothe, José L. Vicario, Eulalia Grau, Lidia Ruiz, Jorge Sánchez, Amalio Telenti, Eloísa Yuste, Christian Brander, Cecilio López- Galíndez

Read full article on Low-replicating viruses and strong anti-viral immune response associated with prolonged disease control in a superinfected HIV-1 LTNP elite controller>

Intradermal Immunization Triggers Epidermal Langerhans Cell Mobilization Required for CD8 T-Cell Immune Responses

Authors: Christelle Liard, Séverine Munier, Alix Joulin-Giet, Olivia Bonduelle, Sabrina Hadam, Darragh Duffy, Annika Vogt, Bernard Verrier and Béhazine Combadière

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Bifunctional CD4-DC-SIGN fusion proteins demonstrate enhanced avidity to gp120 and inhibit HIV-1 infection and dissemination

Authors: Du T, Hu K, Yang J, Jin J, Li C, Stieh D, Griffin GE, Shattock RJ, Hu Q.

Read full article on Bifunctional CD4-DC-SIGN fusion proteins demonstrate enhanced avidity to gp120 and inhibit HIV-1 infection and dissemination>

Highly conserved HIV-1 gp120 glycans proximal to CD4-binding region affect viral infectivity and neutralizing antibody induction

Authors: Huang X, Jin W, Hu K, Luo S, Du T, Griffin GE, Shattock RJ, Hu Q

Read full article on Highly conserved HIV-1 gp120 glycans proximal to CD4-binding region affect viral infectivity and neutralizing antibody induction>

Transferrin conjugation confers mucosal molecular targeting to a model HIV-1 trimeric gp140 vaccine antigen

Authors: Mann JF, Stieh D, Klein K, de Stegmann DS, Cranage MP, Shattock RJ, McKay PF

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Sustained release of the CCR5 inhibitors CMPD167 and maraviroc from vaginal rings in rhesus macaques

Authors: Malcolm RK, Veazey RS, Geer L, Lowry D, Fetherston SM, Murphy DJ, Boyd P, Major I, Shattock RJ, Klasse PJ, Doyle LA, Rasmussen KK, Goldman L, Ketas TJ, Moore JP

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Differential clade-specific HLA-B*3501 association with HIV-1 disease outcome is linked to immunogenicity of a single Gag epitope

Authors: Matthews PC, Koyanagi M, Kløverpris HN, Harndahl M, Stryhn A, Akahoshi T, Gatanaga H, Oka S, Juarez Molina C, Valenzuela Ponce H, Avila Rios S, Cole D, Carlson J, Payne RP, Ogwu A, Bere A, Ndung'u T, Gounder K, Chen F, Riddell L, Luzzi G, Shapiro R, Brander C, Walker B, Sewell AK, Reyes Teran G, Heckerman D, Hunter E, Buus S, Takiguchi M, Goulder PJ

Read full article on Differential clade-specific HLA-B*3501 association with HIV-1 disease outcome is linked to immunogenicity of a single Gag epitope>

Expansion of interferon-g-secreting HIV-specific T cells during successful antiretroviral therapy

Authors: Gasser O, Brander C, Wolbers M, Brown N, Rauch A, Günthard H, Battegay M, Hess C; the Swiss HIV Cohort Study

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Preferential Amplification of CD8 Effector-T Cells after Transcutaneous Application of an Inactivated Influenza Vaccine: A Randomized Phase I Trial

Authors: Combadière B, Vogt A, Mahé B, Costagliola D, Hadam S, Bonduelle O, Sterry W, Staszewski S, Schaefer H, van der Werf S, Katlama C, Autran B, Blume-Peytavi U

Read full article on Preferential Amplification of CD8 Effector-T Cells after Transcutaneous Application of an Inactivated Influenza Vaccine: A Randomized Phase I Trial>

Antiviral breadth and combination potential of peptide triazole HIV-1 entry inhibitors

Authors: McFadden K, Fletcher P, Rossi F, Kantharaju, Umashankara M, Pirrone V, Rajagopal S, Gopi H, Krebs FC, Martin-Garcia J, Shattock RJ, Chaiken I.

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Potential use of protease inhibitors as vaginal and colorectal microbicides

Authors: Herrera C, Shattock RJ

Read full article on Potential use of protease inhibitors as vaginal and colorectal microbicides>

Psychological stress is associated with high levels of IL-6 in HIV-1 infected individuals on effective combined antiretroviral treatment

Authors: Fumaz CR, Gonzalez-Garcia M, Borras X, Muñoz-Moreno JA, Perez-Alvarez N, Mothe B, Brander C, Ferrer MJ, Puig J, Llano A, Fernandez-Castro J, Clotet B

Read full article on Psychological stress is associated with high levels of IL-6 in HIV-1 infected individuals on effective combined antiretroviral treatment>

40 nm, but not 750 or 1,500 nm, Nanoparticles Enter Epidermal CD1a+ Cells after Transcutaneous Application on Human Skin

Authors: Annika Vogt, Behazine Combadiere, Sabrina Hadam, Karola M Stieler, Juergen Lademann, Hans Schaefer, Brigitte Autran, Wolfram Sterry and Ulrike Blume-Peytavi

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Whole genome deep sequencing of HIV-1 reveals the impact of early minor variants upon immune recognition during acute infection

Authors: Henn MR, Boutwell CL, Charlebois P, Lennon NJ, Power KA, Macalalad AR, Berlin AM, Malboeuf CM, Ryan EM, Gnerre S, Zody MC, Erlich RL, Green LM, Berical A, Wang Y, Casali M, Streeck H, Bloom AK, Dudek T, Tully D, Newman R, Axten KL, Gladden AD, Battis L, Kemper M, Zeng Q, Shea TP, Gujja S, Zedlack C, Gasser O, Brander C, Hess C, Günthard HF, Brumme ZL, Brumme CJ, Bazner S, Rychert J, Tinsley JP, Mayer KH, Rosenberg E, Pereyra F, Levin JZ, Young SK, Jessen H, Altfeld M, Birren BW, Walker BD, Allen TM

Read full article on Whole genome deep sequencing of HIV-1 reveals the impact of early minor variants upon immune recognition during acute infection>

T-cell immunity to Kaposi sarcoma-associated herpesvirus: recognition of primary effusion lymphoma by LANA-specific CD4+ T cells

Authors: Sabbah S, Jagne YJ, Zuo J, de Silva T, Ahasan MM, Brander C, Rowland-Jones S, Flanagan KL, Hislop AD

Read full article on T-cell immunity to Kaposi sarcoma-associated herpesvirus: recognition of primary effusion lymphoma by LANA-specific CD4+ T cells>

Viral adaptation to immune selection pressure by HLA class I-restricted CTL responses targeting epitopes in HIV frameshift sequences

Authors: Berger CT, Carlson JM, Brumme CJ, Hartman KL, Brumme ZL, Henry LM, Rosato PC, Piechocka-Trocha A, Brockman MA, Harrigan PR, Heckerman D, Kaufmann DE, Brander C

Read full article on Viral adaptation to immune selection pressure by HLA class I-restricted CTL responses targeting epitopes in HIV frameshift sequences>

Human immunodeficiency virus type-1 (HIV-1) Pr55gag virus-like particles are potent activators of human monocytes

Authors: Speth C, Bredl S, Hagleitner M, Wild J, Dierich M, Wolf H, Schroeder J, Wagner R, Deml L

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